Year: 2014 | Month: March and June | Volume 2 | Issue 1 and 2
Mining of Expressed Sequence Ttags for Identification of ATatP Binding Ccassette Ttransporters in Human Brain
DOI:Coming soon...
Abstract:
The general quality of expressed sequence tag (EST) sequences and the general absence of positive selection in these sequences make ESTs an attractive tool for the study of evolutionary relationship and sequence searches. Due to emerging scope of ABC transporters in human brain diseases treatment investigations and drug resistance, here we investigate the ABC transporter ESTs present in human brain. 15 ESTs were identified and used for cluster generation to see the gaps and subjected to phylogenetic analysis to identify the evolutionary relationship and conserved structures. Investigation and clustering of human ESTs from brain allows extension of data sampling from outside of the genome project.
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